Estudo do papel do estresse oxidativo e dos antioxidantes na infecção por SARS-COV-2: uma revisão sistemática

Abstract

With the arrival of SARS-CoV-2, the world found itself in a war against the disease caused by the virus. This one, which can lead to the compromise of systems, such as the cell cycle, stress, immunological and metabolic systems, leading to impairment of renin-angiotensin, which is involved in the functioning of vital organs. At the same time, there is an imbalance of the redox system, triggered by the storm of inflammatory cytokines, typical of the disease. These imbalances are important points for a worse prognosis of the disease, in addition to the existence of previous diseases and advanced age. For these reasons, much has been speculated about the use of antioxidants to prevent or fight viral. In this context, this systematic review sought to understand the effects of antioxidants on SARS-CoV-2 infection. Using the Medline/Pubmed database, data from retrospective and prospective clinical and observational studies were explored, selecting a total of 25 studies. The sample size ranged from 12 to 4314 individuals and the mean age was 55.27 ± 11.82. Most studies used vitamin D (n=6) as an intervention, followed by vitamin C (n=6) and zinc (n=3). As for the assessment of the quality of studies, an average score of 7.38 points for clinical studies and 9.28 points for observational studies was found, indicating good methodological quality. Although there is some evidence pointing to the benefits of using antioxidants against the disease, it is still not possible to reach a consensus on their real role, which is due to the heterogeneity of the studies and the discrepancy between the published results. [resumo fornecido pelo autor]