Um antigo conhecido, de um jeito diferente: adenovírus como vetor viral para vacinas gênicas

Abstract

The demand for new technologies with high therapeutic potential has driven several studies involving viral vectors, which play a crucial role in oncological treatments and in combating infectious agents. Among them, adenovirus has stood out for providing new alternatives to conventional vaccines. This research, through a narrative review of the literature, explores the use of adenoviruses as vectors, including the development of adenoviral vaccines, their immunological mechanisms, as well as the efficacy and safety of these vaccines. The literature on this topic has been growing in recent years, discussing limitations such as pre-existing vector immunity and possible solutions to achieve a significant protective effect. In a general note, it is observed that the use of adenovirus is a powerful and promising tool in several therapeutic contexts, due to its rapid production on a large scale, its high capacity to infect cells and its ability to induce specific immune responses. [resumo fornecido pelo autor]