O papel do estresse oxidativo na Doença de Crohn: uma revisão narrativa

Abstract

Introduction: Crohn's disease (DC) is part of a set of inflammatory disorders of the gastrointestinal tract of varied symptoms and chronic character. Evidence has shown a positive association between oxidative stress and DC. In this sense, different biomarkers are being studied, but there is still no consensus regarding the results. Objective: To compile the most recent studies on the oxidant/antioxidant balance in DC in active and remission patients. Results: Among the biomarkers, those related to lipid peroxidation were the most studied in DC. It was observed that, even with the disease under control, remissive patients continue to present high levels of oxidative stress (oxidative damage to lipids and proteins) and antioxidant defenses (GPx and catalase activity). In addition, plasma levels of selenium, a mineral with important antioxidant action, were found to be decreased in patients, regardless of the stage of the disease. Conclusion: These findings demonstrate the need to monitor the patient for oxidative stress and antioxidant defense biomarkers, especially in periods of remission, when the patient does not have symptoms, but maintains latent oxidativeinflammatory changes. The data discussed here may contribute to the design and development of new approaches for patients with DC. [resumo fornecido pelo autor]