Transmissão transplacentária do Papilomavírus humano

Abstract

Genital infection by the human Papillomavirus is one of the most frequent sexually transmitted diseases, and about 40 genotypes were detected in female and male anogenital region. The aim of this study was to evaluate the diagnostic efficiency of the colletction methods by brush and PCR, peniscopy and histology for HPV diagnosis of the human Papillomavirus in clinical and subclinical penis infections, as well as to determine epidemiologic contaminated profile male population. A prospective study was carried out in men seeking for treatment at the urology service due to lesion in the penis, as well as in men whose sexual partners are women with either serious or mild lesions in the uterine cervix. The patients have been subjected to epidemiologic interview, peniscopy and to sample collection by brush and biopsy. The collection of methods by brush and PCR, peniscopy and histology, used for the diagnosis of HPV infection, have been assessed in terms of their sensitivity, their specificity and also regarding the ratio between their positive and negative probability. Of the 80 men included in study, 38 (47.5%) were negative for the HPV/DNA, whereas 42 (52.5%) were positive to HPV/DNA, out of whom 29 (36.2%) had clinical infection, 12 (15%) had subclinical infection and one (1.3%) had a latent infection. The performance standards of the diagnostic methods for clinical HPV infection was considered excellent for brush and PCR, histology and peniscopy + histology; brush + PCR were the methods that showed the best performance when used alone for the diagnosis of subclinical HPV infection. The epidemiologic analysis showed an mean age 28,1+9,6 years for HPV/DNA positive group, with a clear prevalence of this infection in people with less age of 29 old. There were significant difference between HPV infection and the following variables: age, marital status-single, first sexual intercourse before 16 old and number of sexual partners in the last 2 or more years.